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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T71584 | Microtubule Inhibitor 185322 | ||
Microtubule inhibitor 185322 is an inhibitor of microtubule assembly, inducung mitotic arrest and apoptosis of MM cells. | |||
T12034 | Microtubule inhibitor 1 | Others | |
Microtubule inhibitor 1 is an antitumor agent with microtubule polymerization inhibitory activity(IC50 = 9-16 nM, in cancer cells). | |||
T62448 | Microtubule inhibitor 6 | ||
Microtubule inhibitor 6 (compound 17o) is a potent microtubule inhibitor. microtubule inhibitor 6 exhibited cytotoxicity against NCI-H460 cells, BxPC-3 cells, and HT-29 cells, with IC50 values of 14.0, 6.6, and 7.0 nM, r... | |||
T61749 | Microtubule inhibitor 2 | ||
Microtubule inhibitor 2 is a highly potent and selective microtubule inhibitor, which is orally active. It induces cell death via ferroptosis, and exhibits notable antitumor activity [1]. | |||
T61765 | Microtubule inhibitor 5 | ||
Microtubule inhibitor 5 (compound 17f) is a highly potent cytotoxic agent that inhibits microtubule function. It exhibits a substantial cytotoxic effect on NCI-H460 cells, with an IC50 value of 154.5 nM. Moreover, this c... | |||
T36850 | Curvulin | Microtubule Associated | |
Curvulin is the active metabolite isolated from Paraphoma sp. VIZR 1.46. Curvularin inhibits iNOS expression and microtubule assembly. | |||
T62642 | Microtubule inhibitor 4 | ||
Microtubule inhibitor 4 (compound 2) is a potent inhibitor of microtubule and inhibits microtubule protein polymerization, HT-29 cells (IC50: 2.1 nM) exhibited cytotoxicity. | |||
T62867 | Microtubule inhibitor 3 | ||
Compounds 17o (IC50: 14.0 nM, NCI-H460) and 17p (IC50: 2.9 nM, NCI-H460) with furan moieties showed potent cytotoxic effects at the nanomolar level against various human cancer cell lines. | |||
T15236 | Entasobulin | Microtubule Associated | |
Entasobulin is an inhibitor of β-tubulin polymerization. It has a potential anticancer activity. | |||
T62639 | Microtubule inhibitor 7 | ||
Compounds 17o (IC50= 14.0 nM, NCI-H460) and 17p (IC50= 2.9 nM, NCI-H460) with furan moieties show potent nanomolar levels of cytotoxic activity against various human cancer cell lines. | |||
T14349 | Auristatin F | Microtubule Associated | |
Auristatin F is an effective inhibitor of microtubule and vascular damaging agent. Auristatin F can be used in antibody-drug conjugates. | |||
T60026 | KIF18A-IN-2 | Microtubule Associated | |
KIF18A-IN-2 is an inhibitor of mitotic kinesin Kif18A with IC50 of 28 nM and can be used in studies about chromosomal instability-associated vulnerabilities. | |||
TN2190 | Scoulerine | Apoptosis , Beta-Secretase , BACE , Parasite | |
Scoulerine is an inhibitor of ß-site amyloid precursor protein cleaving enzyme 1(BACE1). Scoulerine a potent antimitotic compound that inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells. | |||
T9504 | MAP4343 | Microtubule Associated | |
Map4343 is a 3-methyl ether derivative of pregnenolone. Map4343 binds to microtubule associated protein 2 (MAP2) in vitro and stimulates tubulin polymerization, resulting in enhanced neurite extension and protection of n... | |||
T8188 | Podophyllotoxone | Others , Microtubule Associated | |
Podophyllotoxinone, a natural compound found in Dysosma versipellis, shows inhibitory activity against L1210 leukemia and KB cells in vitro. | |||
T39994 | Sovilnesib | Microtubule Associated | |
Sovilnesib is a kinesin-like protein KIF18A inhibitor. Sovilnesib can be used for the cancer research. | |||
T14348 | Auristatin E | Microtubule Associated | |
Auristatin E, a cytotoxic tubulin modifier, disrupts cell division by inhibiting tubulin polymerisation. This compound demonstrates potent and selective antitumor activities, serving as an MMAE analog and cytotoxin in an... | |||
T22661 | CHM-1 | Apoptosis , Others , Microtubule Associated | |
CHM-1 is an inducer of apoptosis, and displays potent antitumor ability in human hepatocellular carcinoma by activation of Cdc2 kinase activity. CHM-1 inhibits tubulin polymerization in vitro and in vivo. | |||
T21632 | Myoseverin | Others , Microtubule Associated | |
Myoseverin, an inducer of the reversible fission of multinucleated myotubes into mononucleated fragments, affecting the expression of a variety of growth factor, immunomodulatory, extracellular matrix-remodeling, and str... | |||
T7800 | TN-16 | Microtubule Associated | |
TN-16 is a microtubule polymerization inhibitor (IC50 :0.4-1.7 μM) |